Figure 4.

Influence of chronic treatment with cannabidiol (CBD) (every 24 h for 14 days, i.p., 10 mg/kg) on the force of contractions of atria isolated from spontaneously hypertensive (SHR) rats and their normotensive control (WKY) undergoing hypoxia/reoxygenation (H/R) with followed stimulation with isoprenaline (ISO; 0.01 nM–30 μM). (A) time course of hypoxia and reoxygenation; positive inotropic response to ISO: (B) expressed as changes in force (delta) of contractions, (C) expressed as percentages of basal values. Data are given as the means ± SEM of 5–7 rats. ^## p < 0.001; SHR significantly different from WKY, one-way analysis of variance (ANOVA) with Bonferroni post hoc test.