Figure 5.

The main mechanisms of action promoted by phenols in MAFLD. A salubrious diet with an increased consumption of fruits and vegetables elevates the intake of polyphenols. These phytochemicals can inhibit liver cellular damage associated with MAFLD through varied mechanisms that may include a decrease in de novo lipogenesis due to the downregulation of SREBP-1c, elevating β-fatty acid oxidation through PPAR α upregulation, ameliorating insulin sensitivity, and reducing oxidative stress and inflammation processes. This scenario is related to a reduction in liver damage and systemic inflammation. JNK: c-Jun N-terminal kinase; NF-KB: nuclear factor kappa B; Nrf2: nuclear factor erythroid 2-related factor 2, PKC: protein kinase C; PPAR-α: peroxisome proliferator-activated receptor gamma; SREBP-1c: Sterol regulatory element-binding protein 1c; TCA: tricarboxylic acid cycle; TAG: triglyceride.