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. 2001 Sep;75(18):8569–8578. doi: 10.1128/JVI.75.18.8569-8578.2001

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Copyright © 2001, American Society for Microbiology

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FIG. 6 — Phenylalanine at position 262 of mouse p48 allows cell-free PyV DNA replication. Increasing enzyme concentrations of pol-prim complexes were tested for their ability to support PyV DNA replication in vitro in human extracts depleted of pol-prim. (A) the activities of hybrid enzyme complexes HHHh(m273–320), HHHh(m257–320), and HHHh(m257–288) were compared with the replication activities of murine pol-prim (MMMM) and human pol-prim (HHHH). (B) The abilities of HHHh(m257–288), HHHh-L266P, HHHh-S262F, and HHHh-S262F/L266P to replicate PyV DNA were measured. For comparison, replication assays with the replication-competent murine pol-prim (MMMM) and replication-inactive human pol-prim (HHHH) were performed in parallel. The data are the mean values and standard deviations of three DNA replication assays.