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. 2024 Sep 28;16(10):1267. doi: 10.3390/pharmaceutics16101267

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The amino acid sequence of the PLR peptide is KRKKKGKGLGKKRDPCLRKYKKLLKLLLKLLLKLLKRRRRRRRR. The images show (A) a simplified molecular-input line-entry system (SMILES) notation, with the heparan-binding domain from heparin-binding epidermal growth factor (P21, red), endosomal escaping sequence (LK15, blue) and cationic polyarginine CPP (8R, purple; produced using the PepSMI tool by NovoPro, https://www.novoprolabs.com/tools/convert-peptide-to-smiles-string, accessed on 22 September 2024) and (B) a two-dimensional model (produced using the PEP-FOLD3 tool [11] https://bioserv.rpbs.univ-paris-diderot.fr/services/PEP-FOLD3/, accessed on 22 September 2024).