Skip to main content
. 2024 Sep 28;16(10):1267. doi: 10.3390/pharmaceutics16101267

Figure 5.

Figure 5

PLR increases oxytocin transcytosis across an RPMI 2650 nasal epithelial cell barrier (cultured on transwell inserts at the air–liquid interface) at concentrations that do not reduce the transepithelial electrical resistance (TEER) or cell viability. The data are shown as the mean ± s.e.m. (with individual data points also shown on the histograms) for (A) the time course of oxytocin accumulation in the basal chamber; (B) apparent permeability (Papp) across the 6 h period as a whole; as well as (C) the TEER across the time course of transcytosis measurements and (D) cell viability at the end of the 6 h period following incubation with oxytocin alone (gray lines/bars) and increasing PLR concentrations (blue lines/bars). #/## p < 0.05/0.01 for both the 1:10 molar oxytocin/PLR ratio versus oxytocin alone and ‡ p < 0.05 for the 1:10 molar oxytocin/PLR ratio versus 1:1 (one-way ANOVA, two-way ANOVA or two-way repeated-measures ANOVA with Geisser–Greenhouse’s correction for unequal variance, all followed by Tukey’s multiple-comparison post hoc test).