FIG. 5.

Effect of changes within the GIV motif on inhibition by T-649 and T-20. JC53-BL cells were infected with each chimeric virus in the presence of increasing concentrations of T-649 (A) or T-20 (B), which are plotted along the horizontal axes. Luciferase activity was measured at 48 h postinfection and was used to calculate the virus infectivity relative to the control, which is plotted along the vertical axes. Shown are the infectivities of NL4.3-based isogenic viruses containing DIV, GIV, or SIM in the T-20 interaction site (residues 36 to 38) in the presence of each inhibitor.