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. 2024 Sep 27;16(5):1094–1111. doi: 10.3390/neurolint16050082

Figure 2.

Figure 2

Effect of RH on LTP in the rat hippocampus (n = 5) group. (A) Time course of total fEPSP activity percentage variation induced by TBS during the treatment of RH in the organotypic-cultured hippocampus. (B) Average of fEPSP total activity 30 to 40 min post-TBS during the dose-dependent treatment of RH (1, 10, and 100 μM). Value of 1 μM (* p < 0.05), value of 10 μM (*** p < 0.001), value of 100 μM (*** p < 0.001) vs. a control group. (C) Time course of total fEPSP activity percentage change induced by TBS during the treatment of SCO vs. SCO + RH in the organotypic cultured hippocampus. (D) Average of fEPSP total activity 30–40 min following TBS during the treatment of SCO and SCO + RH. *** p < 0.001 vs. control group, ### p < 0.001 vs. SCO group. Significant values between the pairs of groups examined by one-way ANOVA in SPSS analysis of LSD variance statistically significant difference test. SCO, scopolamine; RH, rutin hydrate.