Table 2.

Genomic alterations associated with drug resistance.

Drug	Gene Name	Genomic Changes	Effect Associated with Drug Resistance	Reference
Antimony	MRPA	Amplification	Increases drug efflux	[80,92]
	APX	Amplification	Protection from ROS accumulation	[84]
	G6PDH	Amplification	Protection from ROS accumulation	[84,93]
	AQP1	Amplification, Deletion	Reduces drug uptake	[83]
	MDR1	Point mutation	Increases drug efflux	[86]
AmB	SMT	Deletion	Reduces drug uptake	[87]
	SC5D	Point mutation	Alters sterol biosynthesis	[94]
	CYP51	Point mutation	Alters sterol biosynthesis	[88]
	LMT	Deletion, Point mutation	Alters sterol biosynthesis	[67]
Miltefosine	LMT	Deletion	Reduces drug uptake	[89]
Paromomycin	Gene 18S RNA	Point mutation	Decreases binding of PMM	[81]