Figure 9.

Effect of MSCs-derived EVs on the lung injury in vivo at 72 h. Representative images of H&E histological lung sections of control and injured animals with (A) 2.5× and (B) 10× magnification. Scale bars: 200 and 100 µm, respectively. (C) Quantification of the lung injury score (LIS), evaluating hemorrhage, peribronchial infiltration, interstitial edema, pneumocyte hyperplasia and intra-alveolar infiltration, as described in Supplementary Table S3. Data are presented as mean ± SEM (n = 9–14). *** p < 0.001.