Table 1.
Outline of the in vivo study designs.
| Study | Pig ID | Vaccine Virus | Immunization Dose | Challenge Virus | Challenge Virus Dose |
|---|---|---|---|---|---|
| Study #1 Safety Study |
2055 | Mixed population Arm-∆PolX/Arm-∆PolX-∆MGF | 102 pfu intramuscular |
None | Not applicable |
| 2056 | |||||
| 2057 | |||||
| 2059 | |||||
| 1866 | |||||
| 2268 | 104 pfu intramuscular |
||||
| 2271 | |||||
| 2082 | |||||
| 2191 | |||||
| 2199 | |||||
| Study #2 Safety and efficacy Study |
292 | Purified Arm-∆PolX |
102 pfu intramuscular |
Not applicable (All animals died prior to challenge) |
Not applicable |
| 294 | |||||
| 295 | |||||
| 298 | |||||
| 300 | |||||
| 302 | |||||
| 291 | Purified Arm-∆PolX-∆MGF |
102 pfu intramuscular |
Arm/07 | 102 HAD50 intramuscular | |
| 293 | |||||
| 296 | |||||
| 297 | |||||
| 299 | |||||
| 301 | Unvaccinated | Not applicable | Arm/07 | 102 HAD50 intra-muscular | |
| 304 | |||||
| 305 | |||||
| 308 | |||||
| 309 | |||||
| 311 |