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. 2024 Oct 18;12(10):1189. doi: 10.3390/vaccines12101189

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Antibodies induced by vaccination with DV1-AP205/AP205-DV4 do not enhance DENV−2 infection. (A) Fold change of DENV-2 infection of the serum-induced by vaccination with DV1-AP205/AP205-DV4. Day 28 is shown in black, and day 49 is shown in grey. Negative Control (naïve serum) is shown in blue. The serum dilution is shown in log values. (B) Fold change of DENV-2 infection of mouse 4G2 antibody used as a positive control. Antibody concentration is shown in log values. Statistical analysis (mean ± SEM) using one-way ANOVA. Vaccine group n = 6. One representative of two similar experiments is shown. The value of p < 0.05 was considered statistically significant (* p < 0.05, *** p < 0.001, **** p < 0.0001).