Fig. 4.

Schematic of the anti-oxidant, anti-inflammatory, moisturizing, anti-acne, wound-healing, and anti-aging actions of cannabidiol in the skin. AEA N-arachidonoylethanolamine, AQP3 aquaporin 3, CB1R cannabinoid receptor 1, CB2R cannabinoid receptor 2, C. acnes Cutibacterium acnes, H₂O₂ hydrogen peroxide, IL interleukin, MCP-2 monocyte chemotactic protein-2, MMP-9, metalloproteinase-9, NF-κB nuclear factor-kappa B, PGE₂ prostaglandin E2, PPARγ peroxisome proliferator-activated receptor gamma, ROS reactive oxygen species, TNF-α tumor necrosis factor-alpha, TRP transient receptor potential, TRPV4 transient receptor potential cation channel subfamily V member 4, UV ultraviolet