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. 2024 Oct 25;45(1):33. doi: 10.1007/s10875-024-01821-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Proteins differentially expressed between healthy newborn and adult samples. A Heatmap of hierarchical clustering of all differentially expressed proteins (DEPs) detected by comparison between healthy newborn and adult samples. Red, upregulated DEPs; blue, downregulated DEPs. B Volcano plot showing DEPs in dried blood spot samples from healthy newborns compared with those from healthy adults. C Protein–protein interaction network analysis illustrating the top 100 upregulated and downregulated proteins (q-value < 0.05), contrasting healthy newborns and adults; network generated in Cytoscape using the STRING database. Node size corresponds to P value, while colors (red and blue) signify DEPs; red and blue circles represent the 'Hemoglobin complex' and 'Complement and coagulation' Gene Ontology (GO) terms, respectively. D GO enrichment analysis of DEPs. Bar charts showing the top 10 GO terms for biological processes upregulated (left) and downregulated (right) in newborn samples relative to adult samples