Table 2.
Comparison of clinical phenotypes between patients with and without variants in the analyzed genes
| Clinical phenotype | Total | Patients with variants | Patients without variants | p value |
|---|---|---|---|---|
| Age at onset (years)a | 3 (2.0–10.5) | 4 (2.0–7.0) | 3 (1.0–7.0) | 0.2948 |
| Male sex, % (n/N) | 57% (105/185) | 36% (8/22) | 60% (97/163) | 0.0455 |
| Absence of edema, % (n/N) | 16% (24/153) | 50% (9/18) | 11% (15/135) | < 0.0001 |
| Family history, % (n/N) | 2% (3/185) | 5% (1/22) | 1% (2/163) | 0.3175 |
| Extrarenal complications, % (n/N) | 17% (32/185) | 23% (5/22) | 17% (27/163) | 0.5541 |
| NS-AKI with temporary dialysis, % (n/N) | 2% (4/185) | 0% (0/22) | 2% (4/163) | > 0.9999 |
| CKD stage 5, % (n/N) | 9% (17/185) | 18% (4/22) | 8% (13/163) | 0.1250 |
| Complete remission, % (n/N) | 19% (35/185) | 5% (1/22) | 21% (34/163) | 0.0100 |
| Initial histopathologic diagnosis, % (n/N) | 0.2258 | |||
| FSGS | 50% (76/153) | 71% (12/17) | 47% (64/136) | |
| MGA | 41% (62/153) | 24% (4/17) | 43% (58/136) | |
| DMS | 2% (3/153) | 6% (1/17) | 1% (2/136) | |
| DMP | 8% (12/153) | 0% (0/17) | 9% (12/136) |
CKD, chronic kidney disease; DMP, diffuse mesangial proliferation; DMS, diffuse mesangial sclerosis; FSGS, focal segmental glomerular sclerosis; MGA, minor glomerular abnormalities; NS-AKI, acute kidney injury in nephrotic syndrome
aMedian (interquartile range)