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. 2024 Oct 25;15:9237. doi: 10.1038/s41467-024-53545-2

Fig. 1. Neuronal serotonin is important for IgA B cell differentiation and host defense against oral Salmonella infection.

Fig. 1

A Salmonella Typhimurium (STm) CFU burdens in spleens and livers of WT and Tph2−/− mice 5 days post oral inoculation (WT, n = 15; Tph2−/−, n = 17). B Kaplan–Meier plot of survival of WT and Tph2−/− mice following oral STm inoculation (n = 16). C Differential gene expression of CD45+ cells isolated from the lamina propria of the small intestine from co-housed WT and Tph2−/− mice. Red points indicate increased expression and blue points indicate decreased expression in Tph2−/− mice compared to WT mice. D Gene Ontology pathway analysis of data from Fig. 1C. E Flow cytometry analyses of frequency of total B cells, IgD+ fraction of total B cells, and IgA+ cells in the lamina propria CD45+ cells from the small intestine of WT and Tph2−/− mice (n = 9). F Fecal IgA levels in WT and Tph2−/− mice (n = 21). Data shown are means ± SD. Statistical analysis was performed by two-tailed Mann–Whitney test in A, E, F; and by a Log-rank test in B.