Fig. 1. Adoptive transfer of repNP vaccinated mouse sera increases survival in naïve CCHFV infected mice.

Sera stocks for adoptive transfer were confirmed to have CCHFV-specific antibodies via (a) whole virion IgG ELISA and isotype/subtype whole virion IgG ELISA. Naïve WT C57BL6/J mice were treated with sera from repNP or sham vaccinated mice on day −1 (1tx) or days 0 and +3 (2tx) relative to lethal challenge with 100 TCID₅₀ CCHFV strain UG3010. Mice (N = 8) were (b) weighed daily and monitored for (c) survival until day 14 p.i. Dashed lines indicate limit of detection. Significance was calculated using one-way ANOVA; ns P > 0.05, ****P < 0.0001. Data shown as mean plus standard deviation.