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. 2024 Oct 25;7:1390. doi: 10.1038/s42003-024-07071-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — A Histograms (above) and heatmaps (below) showing signal intensity of IgG, ATAC, H3K27ac, and AR peaks across naïve and inflamed bPSC, with biological replicates indicated as R1, R2, and R3. Differential peaks between naïve and inflamed bPSC with AR binding are displayed in three clusters. B Genome browser tracks at the Il1rn, Calcb, Nipal1, Krt6a, and Tmprss2 loci showing IgG, ATAC, H3K27ac, and AR signal in naïve and inflamed bPSC. Black dots represent peaks induced in inflamed bPSC. Track heights are indicated on the right corner for each track. C Enriched transcription factor (TF) DNA motifs at peak loci in each cluster. Shown are TF families on the left with representative TF members in parenthesis and a representative TF logo on the right. D Enrichment of KEGG and Hallmark pathways in genes adjacent to peaks from each cluster.