Table 1.
Demographic and clinical characteristics of the patient populations at baseline
| Atopic Dermatitis | Psoriasis | ||||||
|---|---|---|---|---|---|---|---|
| Pooled | 10 μg/kg | 12 μg/kg | 24 μg/kg | Pooled | 10 μg/kg | 24 μg/kg | |
| Placebo | REZPEG | REZPEG | REZPEG | Placebo | REZPEG | REZPEG | |
| n = 10 | n = 1 | n = 16 | n = 17 | n = 5 | n = 3 | n = 21 | |
| Age, mean (SD), years | 42.5 (19.8) | 27.0 (N/A) | 47.9 (17.5) | 37.5 (16.4) | 42.6 (15.1) | 47.0 (11.3) | 47.5 (13.4) |
| Sex, n (%) | |||||||
| Female | 6 (60.0) | 1 (100.0) | 11 (68.8) | 7 (41.2) | 2 (40.0) | 0 | 9 (42.9) |
| Male | 4 (40.0) | 0 | 5 (31.3) | 10 (58.8) | 3 (60.0) | 3 (100.0) | 12 (57.1) |
| Race, n (%) | |||||||
| American Indian or Alaska Native | 0 | 0 | 0 | 0 | 0 | 0 | 1 (4.8) |
| Asian | 1 (10.0) | 0 | 2 (12.5) | 0 | 0 | 0 | 3 (14.3) |
| Black or African American | 3 (30.0) | 0 | 3 (18.8) | 3 (17.6) | 0 | 0 | 2 (9.5) |
| White | 6 (60.0) | 1 (100.0) | 11 (68.8) | 14 (82.4) | 5 (100.0) | 3 (100.0) | 14 (66.7) |
| Other | 0 | 0 | 0 | 0 | 0 | 0 | 1 (4.8) |
| Ethnicity, n (%) | |||||||
| Hispanic or Latino | 0 | 0 | 3 (18.8) | 7 (41.2) | 0 | 0 | 2 (9.5) |
| Not Hispanic or Latino | 10 (100.0) | 1 (100.0) | 13 (81.3) | 10 (58.8) | 5 (100.0) | 3 (100.0) | 19 (90.5) |
| Weight, mean (SD), kg | 81.1 (22.5) | 74.8 (N/A) | 81.3 (18.5) | 81.6 (20.6) | 83.6 (12.2) | 89.3 (18.5) | 87.9 (18.6) |
| BMI, mean (SD), kg/m2 | 28.2 (7.5) | 25.0 (N/A) | 29.4 (5.4) | 28.7 (5.5) | 29.8 (4.9) | 26.8 (5.2) | 31.2 (6.2) |
| EASI, mean (SD) | 23.7 (7.1) | 27.1 (N/A) | 23.5 (11.2) | 21.9 (5.1) | --- | --- | --- |
| vIGA-AD, n (%) | |||||||
| Moderate | 5 (50.0) | 1 (100.0) | 9 (56.3) | 11 (64.7) | --- | --- | --- |
| Severe | 5 (50.0) | 0 | 7 (43.8) | 6 (35.3) | --- | --- | --- |
| POEM, mean (SD) | 21.2 (5.7) | 25.0 (N/A) | 20.0 (5.2) | 19.6 (7.0) | --- | --- | --- |
| DLQI, mean (SD) | 13.0 (5.9) | 9.0 (N/A) | 12.4 (6.7) | 11.3 (7.2) | --- | --- | --- |
| BSA, mean (SD), m2 | 39.0 (21.6) | 31.0 (N/A) | 33.8 (20.1) | 33.5 (15.8) | 39.6 (21.0) | 22.0 (5.3) | 27.7 (17.4) |
| Itch NRS, mean (SD) | 8.5 (1.3) | 8.0 (N/A) | 7.8 (2.1) | 7.4 (2.5) | 6.2 (3.0) | 8.3 (1.2) | 7.9 (1.9) |
| PASI, mean (SD) | --- | --- | --- | --- | 27.1 (11.9) | 17.6 (2.9) | 19.2 (6.6) |
| PGA, mean (SD) | --- | --- | --- | --- | 4.2 (1.3) | 3.3 (0.6) | 4.5 (0.9) |
| Target lesion TSS, mean (SD) | --- | --- | --- | --- | 7.6 (1.5) | 6.3 (0.6) | 7.6 (1.1) |
BMI body mass index, BSA body surface area, DLQI Dermatology Life Quality Index, EASI Eczema Area and Severity Index, NRS numeric rating scale, PASI Psoriasis Area and Severity Index, PGA Patient's Global Assessment of Disease Severity, POEM Patient-Oriented Eczema Measure, SD standard deviation, sPGA static Physician's Global Assessment, TSS Total Sign Score, vIGA-AD validated Investigator Global Assessment for Atopic Dermatitis.