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. 2024 Sep 27;16(10):1528. doi: 10.3390/v16101528

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HIV-1 and HTLV-1 Gag hexamer structures. (A) The two HIV-1 CA molecules are displayed on the side of the hexamer, with CA_NTD in cyan and CA_CTD in orange. HIV-1 SP1 domains are shown in blue. The PDB codes are HIV-1 (5L93) [109], HTLV-1 CA_NTD (8PUG) [183], and HTLV-1 CA_CTD (8PUH) [183]. The cross-section of the HTLV-1 Gag lattice reconstruction map suggests a distinctive arrangement of the CA_NTD and CA_CTD compared to HIV-1. (B) Shown is the top view of the HIV-1 hexamer structure, which was generated by fitting HIV-1 CA (5L93) into the EM density of the immature HIV-1 lattice (EMD: 4017). The top view of the HTLV-1 Gag hexamer structure shown was generated by fitting CA_NTD and CA_CTD separately into the EM density of the immature HTLV-1 CA lattice (EMD: 17942). The flexible linker between HTLV-1 CA_NTD and CA_CTD is unstructured and is therefore not shown.