Figure 6.

Comparison of MA lattices based on structural data. (A) Schematic representation of the myrMA lattice in the immature and mature states based on the cryo-ET data [170]. The trimer–trimer interactions are mediated by the N-terminal domain in the vicinity of the myr group, while the PI(4,5)P₂ binding pocket is empty. In the mature myrMA lattice, PI(4,5)P₂ is bound to the cleft and myrMA trimer–trimer interactions are formed by the HBR and PI(4,5)P₂. (B) Schematic illustration of the myrMA lattice based on the X-ray structure of myrMA. In this lattice, myrMA–myrMA interaction at the trimer–trimer interface is mediated by the N-terminal residues. Of note, myrMA–myrMA interaction at the trimer–trimer interface places the myr groups (red) in juxtaposition. The HBR and PI(4,5)P₂ binding cleft are also shown. Hexagons and triangles denote C6 and C3 symmetry, respectively.