Table 2.
Characteristics of HTLV-1 carriers and patients with HAM used to determine diagnostic performance.
| HTLV-1 Carriers | Patients with HAM | p-Value | |
|---|---|---|---|
| n = 23 | n = 69 | ||
| Sex: Female | 14 (60.9%) | 55 (79.7%) | 0.10 (a) |
| Age 1 | 53 [50, 69.5] | 67 [60, 72] | 0.02 (b) |
| PVL in PBMCs 1 | 2.57 [0.20, 4.13] | 3.52 [1.90, 5.07] | 0.03 (b) |
| PVL in CSF cells 1 | 1.46 [0.57, 4.59] 2 | 5.32 [3.89, 8.60] 3 | <0.0001 (b) |
| PVL in CSF cells/PVL in PBMCs 1 | 0.93 [0.63, 1.33] 2 | 1.69 [0.92, 3.20] 3 | 0.005 (b) |
| CXCL10 in CSF (pg/mL) 1 | 249.6 [142.0, 322.7] | 1090.5 [598.0, 2247.7] | <0.0001 (b) |
| Neopterin in CSF (pmol/mL) 1 | 3 [2, 4] | 8 [6, 18] | <0.0001 (b) |
Statistical methods: (a) Fisher’s exact test and (b) Mann–Whitney U test. 1 Data are expressed as median [interquartile range]. 2 n = 18, Data for three HTLV-1 carriers were missing, and data for the two HTLV-1 carriers that fell below the detection limit were also not included here. 3 n = 65, Data for four patients with HAM were missing. PVL, HTLV-1 proviral load; PBMCs, peripheral blood mononuclear cells.