Table 6.
Cutoff values and their diagnostic accuracy for each test kit for diagnosing HAM.
| SERO | LU | LU-P | HISCL | UD | Abbott | Elecsys | ESPLINE | INNO-LIA | |
|---|---|---|---|---|---|---|---|---|---|
| Cutoff values for blood | Titer 16× |
COI 1.0 |
COI 1.0 |
COI 1.0 |
COI 1.0 |
S/CO 1.0 |
COI 1.0 |
* | * |
| Sensitivity | 97.1% | 100% | 100% | 84.1% | 100% | 100% | 100% | 100% | 91.3% |
| Specificity | 73.9% | 8.7% | 13.0% | 91.3% | 13.0% | 18.2% | 34.8% | 30.4% | 65.2% |
| Cutoff values equivalent to the 4× titer of the PA method | Titer 4× |
COI 4.7 |
COI 5.4 |
COI 0.15 |
COI 3.3 |
S/CO 2.8 |
COI 2.3 |
n/a | n/a |
| Sensitivity | 100% | 100% | 98.6% | 98.6% | 100% | 98.6% | 100% | n/a | n/a |
| Specificity | 30.4% | 52.2% | 47.8% | 34.8% | 43.5% | 54.5% | 43.5% | n/a | n/a |
| Cutoff values for maximum specificity with 100% sensitivity | Titer 4× |
COI 4.7 |
COI 4.7 |
COI 0.25 |
COI 3.3 |
S/CO 2.5 |
COI 2.5 |
n/a | n/a |
| Sensitivity | 100% | 100% | 100% | 98.6% ** | 100% | 100% | 100% | n/a | n/a |
| Specificity | 30.4% | 52.2% | 47.8% | 39.1% | 43.5% | 54.5% | 56.5% | n/a | n/a |
COI, cutoff index; S/CO, signal-to-cutoff ratio; n/a, not applicable. * Based on the manufacturer’s instructions. ** Sensitivity did not reach 100% because one patient with HAM had COI = 0.