Table 1.
Treatment-related cascade outcome ranges and ICC values across the clinical sites.
| All 16 Sites | 8 OTP Sites | 8 CHC Sites | |||||
|---|---|---|---|---|---|---|---|
| HCV Treatment Cascade Outcome | Study Sample | Range of Outcome [Minimum–Maximum] | ICC (95% CI) |
Range of Outcome [Minimum–Maximum] | ICC (95% CI) |
Range of Outcome [Minimum–Maximum] | ICC (95% CI) |
| Treatment initiation (%) | ITT | 68–96% | 0.086 (0.051, 0.155) |
71–94% | 0.049 (0.004, 0.143) |
68–96% | 0.090 (0.040, 0.244) |
| Treatment completion (%) | mITT | 60–100% | 0.049 (0.008, 0.215) |
60–100% | 0.138 (0.018, 0.490) |
69–87% | not estimable a |
| Overall treatment adherence (mean) | mITT | 68–81% | 0.026 (0.005, 0.054) |
73–81% | not estimable a | 68–79% | 0.059 (0.035, 0.098) |
| SVR test completion (%) | mITT | 54–95% | 0.096 (0.006, 0.177) |
60–95% | 0.128 (0.012, 0.272) |
54–89% | 0.069 (0.004, 0.162) |
| SVR achievement (%) | mITT | 46–90% | 0.070 (0.014, 0.122) |
60–90% | 0.023 (0.004, 0.116) |
46–82% | 0.076 (0.008, 0.145) |
| PP | 77–100% | 0.143 (0.021, 0.422) |
88–100% | 0.073 (0.014, 0.571) |
77–100% | 0.163 (0.013, 0.563) |
|
Note: a Not estimable as the estimated G matrix was not positive definite. Abbreviations: intra-cluster correlation coefficient (ICC), confidence interval (CI), sustained virologic response (SVR), intention-to-treat (ITT), modified intention-to-treat (mITT), per-protocol (PP), opioid treatment program (OTP), community health center (CHC). The treatment adherence outcome is based on non-missing adherence data only.