Circulating concentrations of inflammatory and endothelial markers at presentation in patients with COVID-19 by severity outcome at D7: GeoSentinel (2020–2021). Circulating concentrations of inflammatory and endothelial markers at inclusion including (A) IL-6, (B) VWF-a2, (C) C5a, (D) IL-1Ra, (E) Il-8, (F) sTREM-1, and (G) suPAR stratified by severity outcome at D7. Discharged at D7 (n = 79), hospitalized on ward at D7 (n = 76), and death or ICU (n = 24) includes those who were admitted to the ICU (n = 20) and those who died by D7 (n = 4). Concentrations of C5a (C) have been logged for visualization. Significant p-values (p < 0.05 by Kruskal–Wallis) are in bold. Abbreviations: complement component C5a (C5a), interleukin-1 receptor antagonist (IL-1Ra), interleukin-6 (IL-6), interleukin-8 (IL-8), soluble tumor necrosis factor receptor-1 (sTREM-1), soluble urokinase-type plasminogen activator receptor (suPAR), von Willebrand factor (VWF-a2).