TABLE 1.
Histopathological findings in the liver tissues of LCMV-infected mice
| Mouse strain | Liver infiltrationa at:
|
Mean no. of apoptotic cells/10 HPFb ± SD (n) at:
|
||
|---|---|---|---|---|
| 8 dpi | 15 dpi | 8 dpi | 15 dpi | |
| B6 | ++ | + | 21,0 ± 9,1 (6) | 0,5 ± 0,8 (6) |
| gld | ++ | + | 58,0 ± 3,5 (2)∗ | 1,0 ± 1,4 (2) |
| lpr | + | +/− | 35,0 ± 28,3 (2) | 1,0 ± 1,4 (2) |
| Fas−/− | ++ | + | 0,7 ± 0,8 (3)∗ | 0,0 ± 0,0 (3) |
| gzmA−/− | ++ | + | 4,3 ± 1,7 (3)∗ | 0,5 ± 0,5 (2) |
| gzmB−/− | ++ | + | 1,0 ± 1,0 (2)∗ | 0,5 ± 0,5 (2) |
| gzmA×B−/− | ++ | ++ | 3,3 ± 3,4 (6)∗ | 0,0 ± 0,0 (6) |
| perf−/− | + | ++ | 1,0 ± 1,2 (5)∗ | 0,2 ± 0,4 (6) |
a
Inflammatory infiltrates were assessed on an arbitrary scale ranging from slight (+/−) to moderate (+) to marked (++).
b
HPF, high-power field (×400 enlargement). The mean number of apoptotic cells/10 different HPF/mouse (n = 2 to 6) is shown. ∗, the numbers of apoptotic cells counted were significantly lower or higher than in B6 mice.