Table 2. Genotype and allele distribution of MTHFR C677T and A1298C polymorphisms in the study population and risk analyses of developing T2DM.
| Genotypes/Alleles | Control (n = 272) n (%) | T2DM (n = 445) n (%) | OR (95% CI) | P-value |
|---|---|---|---|---|
| MTHFR C677T | ||||
| CC | 110 (40.44) | 156 (35.06) | 1.000 (reference) | – |
| CT | 135 (49.63) | 222 (49.89) | 1.160 (0.838–1.604) | 0.371 |
| TT | 27 (9.93) | 67 (15.06) | 1.750 (1.052–2.911) | 0.030* |
| C | 355 (65.26) | 534 (60.00) | 1.000 (reference) | – |
| T | 189 (34.74) | 356 (40.00) | 1.252 (1.003–1.563) | 0.047* |
| Dominant model | – | – | 1.258 (0.922–1.716) | 0.148 |
| Recessive model | – | – | 1.608 (1.000–2.586) | 0.048* |
| Overdominant model | – | – | 0.990 (0.732–1.338) | 0.947 |
| MTHFR A1298C | ||||
| AA | 180 (66.18) | 273 (61.35) | 1.000 (reference) | – |
| AC | 88 (32.35) | 153 (34.38) | 1.146 (0.830–1.583) | 0.407 |
| CC | 4 (1.47) | 19 (4.27) | 3.132 (1.048–9.357) | 0.032* |
| A | 448 (82.35) | 699 (78.54) | 1.000 (reference) | – |
| C | 96 (17.65) | 191 (21.46) | 1.275 (0.971–1.674) | 0.080 |
| Dominant model | – | – | 1.233 (0.899–1.690) | 0.193 |
| Recessive model | – | – | 2.988 (1.006–8.879) | 0.039* |
| Overdominant model | – | – | 0.913 (0.662–1.258) | 0.577 |
Notes.
- OR
- adds ratios
- 95% CI
- 95% confidence interval
*
P < 0.05