Table 6. Comparison of the levels of Hcy, TNF- α, IL-6, SOD, and MDA of the different genotypes in the T2DM group.
| Variables | MTHFR C677T | MTHFR A1298C | ||||
|---|---|---|---|---|---|---|
| CC (n = 60) | CT (n = 104) | TT (n = 42) | AA (n = 136) | AC (n = 66) | CC (n = 4) | |
| Hcy (nmol/mL) | 6.61 ± 1.68 | 8.37 ± 3.47 | 9.81 ± 3.91 | 7.55 ± 2.89 | 9.37 ± 3.90 | 8.45 ± 3.04 |
| P-value | 1 | <0.001*** | <0.001*** | 1 | 0.001** | 0.544 |
| TNF- α (pg/mL) | 59.29 ± 21.79 | 73.81 ± 27.15 | 71.88 ± 22.01 | 66.35 ± 16.47 | 66.96 ± 26.21 | 88.46 ± 17.71 |
| P-value | 1 | 0.002** | 0.037* | 1 | 0.300 | 0.185 |
| IL-6 (pg/mL) | 55.31 ± 13.98 | 52.34 ± 19.60 | 50.22 ± 13.10 | 52.34 ± 12.72 | 56.15 ± 31.21 | 52.98 ± 2.97 |
| P-value | 1 | 0.179 | 0.082 | 1 | 0.469 | 0.764 |
| SOD (U/mL) | 56.90 ± 22.90 | 74.44 ± 25.94 | 67.14 ± 22.81 | 70.32 ± 24.66 | 64.72 ± 25.04 | 54.64 ± 17.34 |
| P-value | 1 | 0.059 | 0.268 | 1 | 0.452 | 0.152 |
| MDA (μmol/L) | 3.60 ± 3.22 | 4.18 ± 2.69 | 4.55 ± 2.97 | 4.24 ± 3.09 | 3.78 ± 2.61 | 4.09 ± 0.75 |
| P-value | 1 | 0.219 | 0.133 | 1 | 0.303 | 0.924 |
Notes.
- FBG
- fasting blood glucose
- FMN
- fructosamine
- TC
- total cholesterol
- TG
- triglyceride
- HDL-C
- high density lipoprotein-cholesterol
- LDL-C
- low density lipoprotein-cholesterol
- APOA1
- apolipoprotein A1
- APOB
- apolipoprotein B
- Hcy
- homocysteine
- TNF- α
- tumor necrosis factor alpha
- IL-6
- interleukin 6
- SOD
- superoxide dismutase
- MDA
- malondialdehyde
*
P < 0.05
**
P < 0.01
***
P < 0.001