Fig. 1.
Differences between current practice of MIPD and future practice. The left panel delineates the conventional methodology for optimising antibiotic dosing in current clinical practice, whereas the right panel outlines the proposed advancements for future practice. AI artificial intelligence, AUC/MIC the ratio of the area under the concentration-time curve to MIC, Cmax/MIC the ratio of maximum drug concentration to MIC, MAP maximum a posteriori, MIC minimum inhibitory concentration, MIPD model-informed precision dosing, ML machine learning, PK/PD pharmacokinetic/pharmacodynamic, TDM therapeutic drug monitoring, T>MIC the duration of time that the drug concentration remains above the MIC during a dosing interval