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. 2024 Apr 12;23(4):479–489. doi: 10.1007/s10689-024-00370-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — RNA expression in sulindac and erlotinib treated colon organoids (A) RNA expression of MYC, EGR1, IL33, FOSL1, LGR5 and FOXQ1 in control (C) and sulindac (S) treated organoids derived from uninvolved colon from SPS, FAP, Lynch and control patient cohorts. Bar graphs show the mean and standard error (n = 4–6) of normalized read counts for each gene. (B) RNA expression of MYC, EGR1, IL33, FOSL1, LGR5 and FOXQ1 in control (C) and erlotinib + sulindac combination (ES) treated organoids derived from SSLs from SPS patients and APs from FAP patients. Bar graphs show the mean and standard error (n = 4–6) of normalized read counts for each gene. Statistical significance determined by DESeq2, FDR < 0.05