Table 3.

Change from baseline in mean diurnal IOP over 8AM, 10AM and 4PM at each visit (ITT analysis set)

Visit	FE implant (N = 385)	SE implant (N = 380)	Sham/timolol (N = 385)	FE implant vs sham/timolol	SE implant vs sham/timolol
Day 10
LS mean (SE)	− 8.22 (0.16)	− 8.37 (0.16)	− 7.16 (0.16)	− 1.06 (0.22)	− 1.21 (0.22)
95% CI	(− 8.53, − 7.91)	(− 8.69, − 8.06)	(− 7.47, − 6.85)	(− 1.50, − 0.62)	(− 1.65, − 0.77)
Week 6
LS mean (SE)	− 7.18 (0.15)	− 7.17 (0.16)	− 6.89 (0.15)	− 0.29 (0.22)	− 0.29 (0.22)
95% CI	(− 7.48, − 6.87)	(− 7.48, − 6.87)	(− 7.19, − 6.58)	(− 0.72, 0.13)	(− 0.72, 0.14)
Month 3
LS mean (SE)	− 6.42 (0.17)	− 6.64 (0.17)	− 6.50 (0.17)	0.08 (0.24)	− 0.13 (0.24)
95% CI	(− 6.75, − 6.09)	(− 6.97, − 6.30)	(− 6.83, − 6.17)	(− 0.39, 0.55)	(− 0.60, 0.33)
Month 12
LS mean (SE)	− 5.38 (0.18)	− 5.38 (0.18)	− 6.06 (0.17)	0.68 (0.25)	0.68 (0.24)
95% CI	(− 5.73, − 5.02)	(− 5.73, − 5.03)	(− 6.39, − 5.73)	(0.20, 1.17)	(0.21, 1.15)

CI confidence interval, FE implant fast-eluting travoprost intracameral implant, IOP intraocular pressure, ITT intent-to-treat, LS least squares, SE standard error, SE implant slow-eluting travoprost intracameral implant