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. 2024 Aug 24;28(6):721–725. doi: 10.1007/s40291-024-00735-9
Although the evidence from the literature is very preliminary, fibroblast activation protein inhibitor (FAPI) positron emission tomography (PET) looks promising in urological cancers. FAPI deserves further investigation as a theranostic agent (labeled with 68Ga for imaging and 177Lu for radioligand therapy) in patients affected by urological cancers.
In bladder cancer, FAPI PET seems to enable the detection of metastatic lesions unrevealed at contrast-enhanced computed tomography and deoxy-2-[18F]fluoro-D-glucose PET, in particular small lymph nodes that are frequently missed at primary staging.
Less evidence in the literature is available in prostate cancer, with a conceivable synergic role to prostate-specific membrane antigen PET in the detection of primary tumors, and in renal cell carcinoma.