Fig. 3. Gene communities identified in COPD stable state and exacerbation involve multiple biological functions.

a A heatmap, where columns represent gene communities from stable visits and acute exacerbation events and the rows represent associated biological functions (annotated in blood transcription modules, microRNA targets, transcription factor targets, and Hallmark biological functions). Each cell of the heatmap is colored proportionally to the average Benjamini-Hochberg corrected log₁₀ p value, testing the enrichment of the ith biological function in the jth gene community. b The microRNA regulatory network of the genes belonging to the community EX_182; in blue the genes of the community, yellow the significantly associated microRNAs. The links show regulatory interactions annotated in miRTarBase. COPD chronic obstructive pulmonary disease.