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. 2024 Oct 26;14:25474. doi: 10.1038/s41598-024-76601-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Quantitative analysis of GMR-Gal4/+; UAS-Aβ/+ flies treated with the peptidic fraction.(a) Phenotypic score determined through quantitative analyses using the Flynotyper plugin on ImageJ. Flies treated with the fraction < 10 kDa did not present any significant difference compared with untreated controls (p > 0.5) n = 5. (b) Total vacuole area. Flies treated with the < 10 kDa presented a significantly reduced total area of damage (p = 0.009) compared to control group n = 3. (c) Retinal thickness. Flies treated with the < 10 kDa fraction presented a greater retinal thickness (p = 0.005) than did control flies n = 3. (d) Relative amyloid quantification through a thioflavin assay. Flies treated with the < 10 kDa fraction presented a lower amyloid content than did untreated flies (p = 0.008) triplicate of pool with 10 heads in each. The data are shown as individual values, the mean ± S.E.M. (unpaired t test).