Table 4.

Univariable and multivariable Cox regression analyses for independent predictors of cardiovascular events.

Univariate analysis				Multivariate analysis
Parameters	HR	IC 95%	P	HR	IC 95%	p
Male sex	3.411	1.554–7.488	0 . 002	3.878	1.34–9.804	0.004
Age	0.988	0.959–1.024	0.606
Disease duration	0.990	0.949–1.029	0.561
Digital ulcers	1.302	0.651–2.604	0.455
mRSS	1.014	0.973–1.057	0.506
ATA	1.406	0.687–2.876	0.351
Late NVC pattern	1.526	0.788–2.953	0.210
Significant ILD	2.465	1.150–5.282	0.020	2.500	1.124–5.564	0.025
NYHA class III-IV	2.050	1.118–4.129	0.044	0.603	0.217–1.674	0.401
Pericardial effusion	2.007	0.927–4.345	0.077
TAPSE/sPAP <0.32	2.127	1.091–4.145	0.027	2.439	1.803–4.943	0.030
PVR >5	1.633	0.818 −3.259	0.164
DLCO	0.980	0.958–1.003	0.082
Cardiac index	0.752	0.432–1.307	0.312
BNP	1.002	1.002–1.003	0.020
Serum urate elevation	1.318	0.688–2.527	0.405

Bold values were statistically significant.