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. 2024 Oct 14;17:1455136. doi: 10.3389/fnmol.2024.1455136

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Copyright © 2024 Bieniussa, Stolte, Arampatzi, Engert, Völker, Hagen, Hackenberg and Rak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Audiological evaluation of Stat3^ΔOHC and Stat3^ΔSC. (A) The number of OHCs was not altered, however (B) DPOAE levels were significantly reduced at 12 (p < 0.01), 16, 20 and 24 kHz (p < 0.001) of Stat3^ΔOHC (n = 6) but not of Stat3^ΔSC (n = 6). (C) Click ABR showed an increased hearing level of Stat3^ΔOHC and Stat3^ΔSC up to 20 dB SPL compared to control animals (p < 0.001). (D) In addition, tone ABR performance revealed a significantly reduced hearing level at 12, 20 and 24 kHz (p < 0.05) of Stat3^ΔOHC and at 8 (p < 0.05), 12, 16, 20 and 24 kHz (p < 0.001) of Stat3^ΔSC. Ctrl, Stat3^ΔOHC, Stat3^ΔSC: n = 6. DPOAE and Tone ABR: Ordinary two-way ANOVA with Dunnett’s multiple comparison test. Click ABR: One-way ANOVA with Dunnett’s multiple comparison test. Significances: *p < 0.05, **p < 0.01, ***p < 0.001.