Table 1.
Baseline characteristics stratified by donor age in unmatched cohort.
| <40 years (n=833) |
≥40 years (n=161) |
P-value | |
|---|---|---|---|
| Recipient characteristics | |||
| Age (years) | 57 [44-64] | 57 [49-65] | 0.11 |
| Female sex | 177 (21.2%) | 26 (16.1%) | 0.14 |
| Race | 0.26 | ||
| White | 562 (67.5%) | 120 (74.5%) | |
| Black | 173 (20.8%) | 22 (13.7%) | |
| Hispanic | 79 (9.5%) | 16 (9.9%) | |
| Asian | 14 (1.7%) | 3 (1.9%) | |
| Other | 4 (0.5%) | 0 (0.0%) | |
| Body mass index (kg/m2) | 28.5 ± 5.0 | 28.8 ± 4.6 | 0.58 |
| Recipient blood type | 0.49 | ||
| A | 291 (34.9%) | 56 (34.8%) | |
| AB | 27 (3.2%) | 3 (1.9%) | |
| B | 97 (11.6%) | 14 (8.7%) | |
| O | 418 (50.2%) | 88 (54.7%) | |
| Heart failure etiology | 0.099 | ||
| Non-Ischemic | 435 (52.2%) | 72 (44.7%) | |
| Ischemic | 229 (27.5%) | 53 (32.9%) | |
| Congenital | 27 (3.2%) | 7 (4.3%) | |
| Restrictive | 37 (4.4%) | 7 (4.3%) | |
| Valvular | 13 (1.6%) | 4 (2.5%) | |
| Hypertrophic | 36 (4.3%) | 4 (2.5%) | |
| Other | 16 (1.9%) | 0 (0.0%) | |
| Education level | 0.37 | ||
| High school | 297 (36.6%) | 65 (41.7%) | |
| College | 430 (53.0%) | 79 (50.6%) | |
| Graduate degree | 84 (10.4%) | 12 (7.7%) | |
| Diabetes mellitus | 255 (30.6%) | 37 (23.0%) | 0.052 |
| Cerebrovascular accident | 56 (6.7%) | 11 (6.8%) | 0.96 |
| Prior cardiac surgery | 359 (43.1%) | 73 (45.3%) | 0.60 |
| Pretransplant dialysis | 9 (1.1%) | 2 (1.2%) | 0.86 |
| Total bilirubin (mg/dL) | 0.87 ± 0.77 | 0.85 ± 0.60 | 0.67 |
| Serum creatinine (mg/dL) | 1.21 ± 0.47 | 1.26 ± 0.49 | 0.30 |
| Pretransplant mechanical ventilation | 4 (0.5%) | 0 (0.0%) | 0.38 |
| Intensive care unit at time of transplant | 276 (33.1%) | 43 (26.7%) | 0.11 |
| Intravenous inotropes | 253 (30.4%) | 43 (26.7%) | 0.35 |
| Intra-aortic balloon pump | 129 (15.5%) | 16 (9.9%) | 0.068 |
| Extracorporeal membrane oxygenation | 13 (1.6%) | 1 (0.6%) | 0.35 |
| Impella | 18 (2.2%) | 3 (1.9%) | 0.81 |
| Durable ventricular assist device | 228 (27.4%) | 29 (18.0%) | 0.013 |
| Cardiac index (L/min/m2) | 2.13 ± 0.59 | 2.07 ± 0.61 | 0.22 |
| Donor Characteristics | |||
| Age (years) | 28 [23-33] | 43 [41-45] | <0.001 |
| Female | 125 (15.0%) | 18 (11.2%) | 0.21 |
| Race | <0.001 | ||
| White | 647 (77.7%) | 121 (75.2%) | |
| Black | 85 (10.2%) | 10 (6.2%) | |
| Hispanic | 88 (10.6%) | 22 (13.7%) | |
| Asian | 4 (0.5%) | 7 (4.3%) | |
| Other | 9 (1.1%) | 1 (0.6%) | |
| Body mass index (kg/m2) | 27.5 ± 6.6 | 28.8 ± 5.7 | 0.017 |
| Blood type | 0.20 | ||
| A | 252 (30.3%) | 46 (28.6%) | |
| AB | 2 (0.2%) | 0 (0.0%) | |
| B | 73 (8.8%) | 7 (4.3%) | |
| O | 506 (60.7%) | 108 (67.1%) | |
| Mechanism of death | <0.001 | ||
| Trauma | 378 (45.4%) | 50 (31.1%) | |
| Cerebrovascular | 59 (7.1%) | 26 (16.1%) | |
| Drug overdose | 193 (23.2%) | 37 (23.0%) | |
| Other | 203 (24.4%) | 48 (29.8%) | |
| Cocaine use | 215 (27.7%) | 46 (33.3%) | 0.18 |
| Diabetes mellitus | 15 (1.8%) | 9 (5.7%) | 0.004 |
| Hypertension | 245 (29.4%) | 69 (42.9%) | <0.001 |
| Serum creatinine (mg/dL) | 1.12 ± 1.40 | 1.28 ± 2.03 | 0.24 |
| Graft left ventricular ejection fraction <50% | 10 (1.2%) | 1 (0.6%) | 0.52 |
| Positive Cytomegalovirus serology | 465 (56.6%) | 81 (51.3%) | 0.21 |
| Hepatitis C | 67 (8.0%) | 19 (11.8%) | 0.12 |
| Matching and Transplant Characteristics | |||
| Sex matched | 703 (84.4%) | 139 (86.3%) | 0.53 |
| Race matched | 485 (58.2%) | 96 (59.6%) | 0.74 |
| Human leukocyte antigen matched (≤3 loci mismatch) | 93 (11.2%) | 15 (9.3%) | 0.49 |
| ABO matched | 723 (86.8%) | 138 (85.7%) | 0.71 |
| Cytomegalovirus matched | 401 (48.8%) | 95 (60.1%) | 0.009 |
| Waitlist time (days) | 33 [9-182] | 37 [11-200] | 0.49 |
| Donor distance to transplanting center (nautical miles) | 340 [136-566] | 237 [51-524] | 0.005 |
| Graft preservation time (hours) | 5.0 [3.5-6.5] | 4.4 [2.7-6.2] | 0.040 |
| Redo transplantation | 17 (2.0%) | 0 (0.0%) | 0.067 |
| Status at time of transplantation | 0.008 | ||
| 1 | 22 (2.6%) | 0 (0.0%) | |
| 2 | 288 (34.6%) | 51 (31.7%) | |
| 3 | 148 (17.8%) | 22 (13.7%) | |
| 4 | 254 (30.5%) | 52 (32.3%) | |
| 5 | 1 (0.1%) | 2 (1.2%) | |
| 6 | 120 (14.4%) | 34 (21.1%) |