Table 1.
Patient and tumor characteristics
| Characteristic | n (%) |
|---|---|
| Sex | |
| Male | 7 (46.6) |
| Female | 8 (53.3) |
| Age (y), median (range) | 74.1 (55.7-85.5) |
| Risk factors | |
| COPD | 8 (53.3) |
| ECOG performance status, median (range) | 2 (0-2) |
| FEV1, median % (range) | 70.0 (36-107) |
| DLCO, median % (range) | 62.0 (32-96) |
| Histology | |
| Adenocarcinoma | 6 (40.0) |
| SCC | 6 (40.0) |
| Other | 3 (20.0) |
| Ultracentral tumor location | |
| Hilum | 6 (40.0) |
| Mediastinum | 4 (26.7) |
| Mediastinum + hilum | 3 (20.0) |
| Parenchyma | 2 (13.3) |
| Prior chemotherapy | |
| Yes | 11 (73.3) |
| No | 4 (26.7) |
| PET maximum SUV prior to treatment, median (range) | 10.9 (4.4-21.8) |
| Patient disease status prior to reirradiation | |
| Local/local-regional recurrence without DM | 13 (86.6) |
| Dominant progression hilar/mediastinal disease with limited DM | 2 (13.3) |
| Initial stage at diagnosis | |
| IA | 1 (6.7) |
| IIA | 1 (6.7) |
| IIB | 1 (6.7) |
| IIIA | 8 (53.3) |
| IIIB | 3 (20.0) |
| IVA | 1 (6.7) |
| Follow-up time (mo) following thoracic reirradiation, median (range) | 10.3 (2.2-79.3) |
Abbreviations: DM = distant metastasis; PET = positron emission tomography; COPD = Chronic obstructive pulmonary disease; ECOG = Eastern Cooperative Oncology Group; FEV1 = Forced expiratory volume in one second; DLCO = Diffusing capacity of lungs for carbon monoxide; SCC = Squamous carcinoma; SUV = Standardized uptake value.