Table 4.
Detailed description of individual patient disease status, dosimetry, treatment outcomes, and toxicity
| Patient no. | Disease status prior to re-RT | Recurrent tumor location (PTV size in cc) | Interval from prior RT (mo) | Cumulative dosimetric parameters in Dmax (Gy) or % for V20 (EQD2, α/β = 3) | Late toxicity (grade) (pneumonitis [P], esophagitis [E], airway [A], and hemorrhage [H]) | Patient status (follow-up time, mo) | Local tumor control | Cause of death (treatment relationship) |
|---|---|---|---|---|---|---|---|---|
| 1 | r-LDM | Hilum + mediastinum (43) | 16.2 | L V20:26; E:100; B:155; V:217 | P:0; E:0; A:0; H:0 | Alive (7) | Yes | - |
| 2 | r-NM | Hilum + mediastinum (75) | 23.5 | L V20:33; E:148; B:204; V:193 | P:1; E:0; A:0; H:0 | Dead (2) | Yes | Unrelated |
| 3 | r-NM | Hilum (65) | 60.2 | L V20:24; E:108; B:194; V:220 | P:1; E:0; A:0; H:0 | Dead (47) | No | Unrelated |
| 4 | r-NM | Mediastinum (35) | 3.6 | L V20:11; E:93; B:85; V:262 | P:1; E:0; A:0; H:0 | Dead (33) | No | Unrelated |
| 5 | r-NM | Hilum (149) | 18.3 | L V20:33; E:148; B:197; V:202 | P:2; E:0; A:0; H:0 | Dead (25) | No | Unrelated (POD) |
| 6 | r-NM | Mediastinum (36) | 12.3 | L V20:13; E:93; B:119; V:201 | P:2; E:0; A:0; H:0 | Dead (5) | Yes | Unrelated (COPD) |
| 7 | r-NM | Hilum (17) | 50.1 | L V20:37; E:94; B:114; V:200 | P:1; E:0; A:0; H:0 | Alive (36) | Yes | - |
| 8 | r-NM | Parenchyma (47) | 10.4 | L V20:43; E:74; B:139; V:191 | P:1; E:0; A:0; H:0 | Dead (5) | Yes | Unrelated (Sepsis) |
| 9 | r-NM | Mediastinum (59) | 35.3 | L V20:28; E:80; B:183; V:183 | P:2; E:0; A:0; H:0 | Alive (27) | Yes | - |
| 10 | r-NM | Hilum + mediastinum (85) | 9.6 | L V20:39; E:83; B:170; V:174 | P:0; E:0; A:0; H:0 | Dead (10) | No | Unrelated |
| 11 | r-NM | Parenchyma (85) | 39.2 | L V20:51; E:96; B:77; V:159 | P:0; E:0; A:0; H:0 | Dead (3) | Yes | Unrelated |
| 12 | r-LDM | Hilum (49) | 22.9 | L V20:17; E:56; B:180; V:186 | P:2; E:0; A:0; H:0 | Dead (9) | Yes | Unrelated (POD) |
| 13 | r-NM | Hilum (67) | 4.6 | L V20:45; E:84; B:155; V:150 | P:3; E:0; A:0; H:0 | Dead (3) | No | Unrelated (Cardiac arrest) |
| 14 | r-NM | Mediastinum (25) | 8.2 | L V20:48; E:103; B:187; V:129 | P:0; E:0; A:0; H:0 | Dead (80) | No | Unrelated (POD) |
| 15 | r-NM | Hilum (13) | 13.3 | L V20:38; E:50; B:163; V:168 | P:0; E:0; A:0; H:0 | Dead (14) | Yes | Unrelated |
Abbreviations: Dmax = maximum dose; EQD2 = equivalent total doses in 2 Gy fractions; PTV = planning target volume; RT = radiation therapy; r-LDM = recurrence at local disease and metastasis; r-NM = local recurrence without metastasis; V20 = volume receiving 20 Gy; L = lung; E = esophagus; B = bronchus; V = great vessels.