Comparison 1. Fluoxetine versus TCAs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond ‐ HDRS (‐50%)	24	2124	Odds Ratio (M‐H, Random, 95% CI)	0.97 [0.77, 1.22]
1.1 Fluoxetine vs Amitriptyline	11	777	Odds Ratio (M‐H, Random, 95% CI)	0.93 [0.68, 1.28]
1.2 Fluoxetine vs Clomipramine	1	94	Odds Ratio (M‐H, Random, 95% CI)	0.63 [0.27, 1.45]
1.3 Fluoxetine vs Desipramine	2	84	Odds Ratio (M‐H, Random, 95% CI)	1.70 [0.56, 5.15]
1.4 Fluoxetine vs Dothiepin/dosulepin	2	144	Odds Ratio (M‐H, Random, 95% CI)	2.13 [1.08, 4.20]
1.5 Fluoxetine vs Doxepine	1	40	Odds Ratio (M‐H, Random, 95% CI)	1.0 [0.28, 3.54]
1.6 Fluoxetine vs Imipramine	5	761	Odds Ratio (M‐H, Random, 95% CI)	0.74 [0.41, 1.35]
1.7 Fluoxetine vs Lofepramine	1	183	Odds Ratio (M‐H, Random, 95% CI)	0.99 [0.55, 1.78]
1.8 Fluoxetine vs Trimipramine	1	41	Odds Ratio (M‐H, Random, 95% CI)	2.05 [0.56, 7.45]
2 End‐point score on rating scale	50	3393	Std. Mean Difference (IV, Random, 95% CI)	0.03 [‐0.07, 0.14]
2.1 Fluoxetine vs Amiptriptyline	19	1023	Std. Mean Difference (IV, Random, 95% CI)	0.10 [‐0.09, 0.29]
2.2 Fluoxetine vs Clomipramine	5	372	Std. Mean Difference (IV, Random, 95% CI)	‐0.10 [‐0.31, 0.10]
2.3 Fluoxetine vs Desipramine	4	147	Std. Mean Difference (IV, Random, 95% CI)	0.27 [‐0.32, 0.86]
2.4 Fluoxetine vs Dothiepin/dosulepin	4	266	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.27, 0.59]
2.5 Fluoxetine vs Imipramine	12	1063	Std. Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.21, 0.19]
2.6 Fluoxetine vs Lofepramine	1	183	Std. Mean Difference (IV, Random, 95% CI)	0.13 [‐0.16, 0.42]
2.7 Fluoxetine vs Nomifensine	1	28	Std. Mean Difference (IV, Random, 95% CI)	‐0.37 [‐1.12, 0.38]
2.8 Fluoxetine vs Nortriptyline	2	251	Std. Mean Difference (IV, Random, 95% CI)	‐0.48 [‐1.20, 0.24]
2.9 Fluoxetine vs Trimipramine	2	60	Std. Mean Difference (IV, Random, 95% CI)	0.41 [‐0.10, 0.92]
3 Failure to complete ‐ Total	49	4194	Odds Ratio (M‐H, Random, 95% CI)	0.79 [0.65, 0.96]
3.1 Fluoxetine vs Amitriptyline	18	1089	Odds Ratio (M‐H, Random, 95% CI)	0.62 [0.46, 0.85]
3.2 Fluoxetine vs Clomipramine	2	263	Odds Ratio (M‐H, Random, 95% CI)	0.65 [0.38, 1.14]
3.3 Fluoxetine vs Desipramine	2	104	Odds Ratio (M‐H, Random, 95% CI)	0.44 [0.16, 1.24]
3.4 Fluoxetine vs Dothiepin/dosulepin	5	478	Odds Ratio (M‐H, Random, 95% CI)	1.57 [0.92, 2.69]
3.5 Fluoxetine vs Doxepine	4	323	Odds Ratio (M‐H, Random, 95% CI)	0.81 [0.49, 1.32]
3.6 Fluoxetine vs Imipramine	12	1225	Odds Ratio (M‐H, Random, 95% CI)	0.79 [0.51, 1.21]
3.7 Fluoxetine vs Lofepramine	1	183	Odds Ratio (M‐H, Random, 95% CI)	0.50 [0.24, 1.04]
3.8 Fluoxetine vs Nomifensine	1	40	Odds Ratio (M‐H, Random, 95% CI)	6.33 [0.67, 60.16]
3.9 Fluoxetine vs Nortriptyline	3	448	Odds Ratio (M‐H, Random, 95% CI)	0.73 [0.36, 1.47]
3.10 Fluoxetine vs Trimipramine	1	41	Odds Ratio (M‐H, Random, 95% CI)	2.0 [0.41, 9.78]
4 Failure to complete ‐ Inefficacy	33	2911	Odds Ratio (M‐H, Random, 95% CI)	1.29 [0.96, 1.72]
4.1 Fluoxetine vs Amitriptyline	13	835	Odds Ratio (M‐H, Random, 95% CI)	0.91 [0.44, 1.88]
4.2 Fluoxetine vs Clomipramine	1	120	Odds Ratio (M‐H, Random, 95% CI)	7.37 [0.37, 145.75]
4.3 Fluoxetine vs Desipramine	2	104	Odds Ratio (M‐H, Random, 95% CI)	1.03 [0.20, 5.35]
4.4 Fluoxetine vs Dothiepin/dosulepin	3	271	Odds Ratio (M‐H, Random, 95% CI)	1.34 [0.49, 3.66]
4.5 Fluoxetine vs Doxepine	3	283	Odds Ratio (M‐H, Random, 95% CI)	1.72 [0.60, 4.92]
4.6 Fluoxetine vs Imipramine	10	1093	Odds Ratio (M‐H, Random, 95% CI)	1.41 [0.97, 2.05]
4.7 Fluoxetine vs Nortriptyline	1	205	Odds Ratio (M‐H, Random, 95% CI)	0.38 [0.07, 2.03]
5 Failure to complete ‐ Side Effects	40	3647	Odds Ratio (M‐H, Random, 95% CI)	0.55 [0.40, 0.75]
5.1 Fluoxetine vs Amitriptyline	16	1038	Odds Ratio (M‐H, Random, 95% CI)	0.41 [0.23, 0.71]
5.2 Fluoxetine vs Clomipramine	2	263	Odds Ratio (M‐H, Random, 95% CI)	0.30 [0.12, 0.79]
5.3 Fluoxetine vs Desipramine	2	104	Odds Ratio (M‐H, Random, 95% CI)	0.27 [0.04, 1.68]
5.4 Fluoxetine vs Dothiepin/dosulepin	5	478	Odds Ratio (M‐H, Random, 95% CI)	2.05 [0.59, 7.16]
5.5 Fluoxetine vs Doxepine	3	283	Odds Ratio (M‐H, Random, 95% CI)	0.82 [0.44, 1.53]
5.6 Fluoxetine vs Imipramine	10	1093	Odds Ratio (M‐H, Random, 95% CI)	0.47 [0.26, 0.86]
5.7 Fluoxetine vs Lofepramine	1	183	Odds Ratio (M‐H, Random, 95% CI)	0.16 [0.02, 1.38]
5.8 Fluoxetine vs Nortriptyline	1	205	Odds Ratio (M‐H, Random, 95% CI)	0.86 [0.42, 1.77]