Comparison 2. Fluoxetine versus heterocyclics.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond ‐ HDRS (‐50%)	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Fluoxetine vs Maprotiline	2	163	Odds Ratio (M‐H, Random, 95% CI)	1.95 [0.91, 4.18]
1.2 Fluoxetine vs Mianserin	1	53	Odds Ratio (M‐H, Random, 95% CI)	0.80 [0.27, 2.38]
2 End‐point score on rating scale	8		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Fluoxetine vs Maprotiline	5	433	Std. Mean Difference (IV, Random, 95% CI)	0.04 [‐0.15, 0.23]
2.2 Fluoxetine vs Mianserin	3	128	Std. Mean Difference (IV, Random, 95% CI)	0.43 [‐0.38, 1.23]
3 Failure to complete ‐ Total	6		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Fluoxetine vs Maprotiline	4	351	Odds Ratio (M‐H, Random, 95% CI)	1.75 [0.90, 3.41]
3.2 Fluoxetine vs Mianserin	2	93	Odds Ratio (M‐H, Random, 95% CI)	0.63 [0.18, 2.25]
4 Failure to complete ‐ Inefficacy	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Fluoxetine vs Maprotiline	3	209	Odds Ratio (M‐H, Random, 95% CI)	2.54 [0.33, 19.19]
4.2 Fluoxetine vs Mianserin	1	53	Odds Ratio (M‐H, Random, 95% CI)	2.27 [0.38, 13.63]
5 Failure to complete ‐ Side Effects	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Fluoxetine vs Maprotiline	3	209	Odds Ratio (M‐H, Random, 95% CI)	0.53 [0.15, 1.93]
5.2 Fluoxetine vs Mianserin	1	53	Odds Ratio (M‐H, Random, 95% CI)	1.05 [0.23, 4.70]