Comparison 3. Fluoxetine versus other SSRIs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond ‐ HDRS (‐50%)	17		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Fluoxetine vs Citalopram	1	59	Odds Ratio (M‐H, Random, 95% CI)	0.60 [0.20, 1.79]
1.2 Fluoxetine vs Escitalopram	1	240	Odds Ratio (M‐H, Random, 95% CI)	1.02 [0.56, 1.85]
1.3 Fluoxetine vs Fluvoxamine	1	177	Odds Ratio (M‐H, Random, 95% CI)	0.95 [0.52, 1.74]
1.4 Fluoxetine vs Paroxetine	9	1574	Odds Ratio (M‐H, Random, 95% CI)	1.23 [0.93, 1.65]
1.5 Fluoxetine vs Sertraline	6	1188	Odds Ratio (M‐H, Random, 95% CI)	1.37 [1.08, 1.74]
2 End‐point score on rating scales	21		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Fluoxetine vs Citalopram	3	661	Std. Mean Difference (IV, Random, 95% CI)	0.06 [‐0.10, 0.21]
2.2 Fluoxetine vs Escitalopram	1	231	Std. Mean Difference (IV, Random, 95% CI)	0.07 [‐0.19, 0.33]
2.3 Fluoxetine vs Paroxetine	11	2061	Std. Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.26, 0.24]
2.4 Fluoxetine vs Sertraline	7	1160	Std. Mean Difference (IV, Random, 95% CI)	0.09 [‐0.03, 0.20]
3 Failure to complete ‐ Total	25		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Fluoxetine vs Citalopram	3	732	Odds Ratio (M‐H, Random, 95% CI)	0.87 [0.60, 1.27]
3.2 Fluoxetine vs Escitalopram	2	578	Odds Ratio (M‐H, Random, 95% CI)	1.53 [1.00, 2.37]
3.3 Fluoxetine vs Fluvoxamine	2	284	Odds Ratio (M‐H, Random, 95% CI)	0.71 [0.36, 1.37]
3.4 Fluoxetine vs Paroxetine	10	1848	Odds Ratio (M‐H, Random, 95% CI)	0.98 [0.81, 1.20]
3.5 Fluoxetine vs Sertraline	9	1591	Odds Ratio (M‐H, Random, 95% CI)	1.17 [0.93, 1.49]
4 Failure to complete ‐ Inefficacy	13		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Fluoxetine vs Citalopram	3	732	Odds Ratio (M‐H, Random, 95% CI)	0.87 [0.48, 1.56]
4.2 Fluoxetine vs Escitalopram	2	578	Odds Ratio (M‐H, Random, 95% CI)	1.74 [0.46, 6.53]
4.3 Fluoxetine vs Paroxetine	4	1005	Odds Ratio (M‐H, Random, 95% CI)	0.75 [0.41, 1.39]
4.4 Fluoxetine vs Sertraline	5	1056	Odds Ratio (M‐H, Random, 95% CI)	1.09 [0.68, 1.77]
5 Failure to complete ‐ Side Effects	23		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Fluoxetine vs Citalopram	3	732	Odds Ratio (M‐H, Random, 95% CI)	0.64 [0.34, 1.20]
5.2 Fluoxetine vs Escitalopram	2	578	Odds Ratio (M‐H, Random, 95% CI)	1.17 [0.64, 2.12]
5.3 Fluoxetine vs Fluvoxamine	1	100	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.14, 7.71]
5.4 Fluoxetine vs Paroxetine	9	1509	Odds Ratio (M‐H, Random, 95% CI)	0.85 [0.62, 1.16]
5.5 Fluoxetine vs Sertraline	9	1591	Odds Ratio (M‐H, Random, 95% CI)	1.25 [0.92, 1.70]