Comparison 4. Fluoxetine versus SNRIs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond ‐ HDRS (‐50%)	15		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Fluoxetine vs Duloxetine	1	103	Odds Ratio (M‐H, Random, 95% CI)	1.41 [0.61, 3.25]
1.2 Fluoxetine vs Milnacipran	2	370	Odds Ratio (M‐H, Random, 95% CI)	1.20 [0.78, 1.84]
1.3 Fluoxetine vs Venlafaxine	12	3387	Odds Ratio (M‐H, Random, 95% CI)	1.29 [1.10, 1.51]
2 End‐point score on rating scale	15		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Fluoxetine vs Milnacipran	2	213	Std. Mean Difference (IV, Random, 95% CI)	‐0.36 [‐0.63, ‐0.08]
2.2 Fluoxetine vs Venlafaxine	13	3097	Std. Mean Difference (IV, Random, 95% CI)	0.10 [0.00, 0.19]
3 Failure to complete ‐ Total	19		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Fluoxetine vs Duloxetine	2	532	Odds Ratio (M‐H, Random, 95% CI)	0.90 [0.53, 1.52]
3.2 Fluoxetine vs Milnacipran	3	560	Odds Ratio (M‐H, Random, 95% CI)	0.98 [0.68, 1.42]
3.3 Fluoxetine vs Venlafaxine	14	2683	Odds Ratio (M‐H, Random, 95% CI)	0.89 [0.74, 1.06]
4 Failure to complete ‐ Inefficacy	18		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Fluoxetine vs Duloxetine	2	432	Odds Ratio (M‐H, Random, 95% CI)	3.33 [0.92, 12.11]
4.2 Fluoxetine vs Milnacipran	3	560	Odds Ratio (M‐H, Random, 95% CI)	1.25 [0.68, 2.30]
4.3 Fluoxetine vs Venlafaxine	13	2640	Odds Ratio (M‐H, Random, 95% CI)	1.31 [0.91, 1.89]
5 Failure to complete ‐ Side Effects	18		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Fluoxetine vs Duloxetine	2	532	Odds Ratio (M‐H, Random, 95% CI)	0.28 [0.07, 1.23]
5.2 Fluoxetine vs Milnacipran	3	560	Odds Ratio (M‐H, Random, 95% CI)	1.50 [0.81, 2.76]
5.3 Fluoxetine vs Venlafaxine	13	2640	Odds Ratio (M‐H, Random, 95% CI)	0.72 [0.56, 0.94]