Comparison 5. Fluoxetine versus MAOIs or newer ADs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond ‐ HDRS (‐50%)	16		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Fluoxetine vs Agomelatine	1	515	Odds Ratio (M‐H, Random, 95% CI)	1.44 [0.99, 2.09]
1.2 Fluoxetine vs Mirtazapine	4	600	Odds Ratio (M‐H, Random, 95% CI)	1.46 [1.04, 2.04]
1.3 Fluoxetine vs Moclobemide	7	721	Odds Ratio (M‐H, Random, 95% CI)	1.27 [0.92, 1.75]
1.4 Fluoxetine vs Phenelzine	1	40	Odds Ratio (M‐H, Random, 95% CI)	1.42 [0.27, 7.34]
1.5 Fluoxetine vs Reboxetine	3	721	Odds Ratio (M‐H, Random, 95% CI)	0.77 [0.55, 1.10]
2 End‐point score on rating scales	13		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Fluoxetine vs Agomelatine	3	1213	Std. Mean Difference (IV, Random, 95% CI)	0.02 [‐0.18, 0.23]
2.2 Fluoxetine vs Mirtazapine	1	31	Std. Mean Difference (IV, Random, 95% CI)	0.57 [‐0.15, 1.29]
2.3 Fluoxetine vs Moclobemide	6	540	Std. Mean Difference (IV, Random, 95% CI)	0.13 [‐0.04, 0.30]
2.4 Fluoxetine vs Phenelzine	1	40	Std. Mean Difference (IV, Random, 95% CI)	‐0.05 [‐0.67, 0.57]
2.5 Fluoxetine vs Reboxetine	2	205	Std. Mean Difference (IV, Random, 95% CI)	0.04 [‐0.31, 0.40]
3 Failure to complete ‐ Total	17		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Fluoxetine vs Agomelatine	2	785	Odds Ratio (M‐H, Random, 95% CI)	1.22 [0.59, 2.49]
3.2 Fluoxetine vs Mirtazapine	3	301	Odds Ratio (M‐H, Random, 95% CI)	0.92 [0.51, 1.68]
3.3 Fluoxetine vs Moclobemide	7	721	Odds Ratio (M‐H, Random, 95% CI)	1.01 [0.70, 1.47]
3.4 Fluoxetine vs Phenelzine	1	40	Odds Ratio (M‐H, Random, 95% CI)	0.18 [0.01, 4.01]
3.5 Fluoxetine vs Reboxetine	4	764	Odds Ratio (M‐H, Random, 95% CI)	0.60 [0.44, 0.83]
4 Failure to complete ‐ Inefficacy	16		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Fluoxetine vs Agomelatine	2	785	Odds Ratio (M‐H, Random, 95% CI)	1.08 [0.41, 2.88]
4.2 Fluoxetine vs Mirtazapine	4	600	Odds Ratio (M‐H, Random, 95% CI)	1.45 [0.71, 2.96]
4.3 Fluoxetine vs Moclobemide	6	679	Odds Ratio (M‐H, Random, 95% CI)	0.70 [0.32, 1.56]
4.4 Fluoxetine vs Phenelzine	1	40	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.5 Fluoxetine vs Reboxetine	3	464	Odds Ratio (M‐H, Random, 95% CI)	0.92 [0.47, 1.77]
5 Failure to complete ‐ Side Effects	16		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Fluoxetine vs Agomelatine	2	785	Odds Ratio (M‐H, Random, 95% CI)	1.50 [0.73, 3.08]
5.2 Fluoxetine vs Mirtazapine	4	600	Odds Ratio (M‐H, Random, 95% CI)	0.95 [0.54, 1.66]
5.3 Fluoxetine vs Moclobemide	7	721	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.54, 2.01]
5.4 Fluoxetine vs Phenelzine	1	40	Odds Ratio (M‐H, Random, 95% CI)	0.32 [0.01, 8.26]
5.5 Fluoxetine vs Reboxetine	2	211	Odds Ratio (M‐H, Random, 95% CI)	0.40 [0.10, 1.61]