Comparison 6. Fluoxetine versus other conventional psychotropic drugs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond ‐ HDRS (‐50%)	8		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Fluoxetine vs Amineptine	1	63	Odds Ratio (M‐H, Random, 95% CI)	0.37 [0.13, 1.04]
1.2 Fluoxetine vs Bupropion	2	436	Odds Ratio (M‐H, Random, 95% CI)	0.83 [0.48, 1.43]
1.3 Fluoxetine vs Pramipexole	1	105	Odds Ratio (M‐H, Random, 95% CI)	0.55 [0.24, 1.26]
1.4 Fluoxetine vs Tianeptine	1	387	Odds Ratio (M‐H, Random, 95% CI)	1.12 [0.75, 1.67]
1.5 Fluoxetine vs Trazodone	3	110	Odds Ratio (M‐H, Random, 95% CI)	0.49 [0.13, 1.86]
2 End‐point score on rating scales	13		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Fluoxetine vs ABT‐200	1	141	Std. Mean Difference (IV, Random, 95% CI)	‐1.85 [‐2.25, ‐1.45]
2.2 Fluoxetine vs Amisulpride	1	268	Std. Mean Difference (IV, Random, 95% CI)	0.17 [‐0.07, 0.41]
2.3 Fluoxetine vs Nefazodone	4	271	Std. Mean Difference (IV, Random, 95% CI)	‐0.06 [‐0.30, 0.18]
2.4 Fluoxetine vs Tianeptine	3	730	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.40, 0.10]
2.5 Fluoxetine vs Trazodone	4	203	Std. Mean Difference (IV, Random, 95% CI)	‐0.25 [‐0.76, 0.26]
3 Failure to complete ‐ Total	17		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Fluoxetine vs ABT‐200	1	144	Odds Ratio (M‐H, Random, 95% CI)	0.18 [0.08, 0.39]
3.2 Fluoxetine vs Amineptine	2	232	Odds Ratio (M‐H, Random, 95% CI)	0.61 [0.17, 2.21]
3.3 Fluoxetine vs Amisulpride	1	281	Odds Ratio (M‐H, Random, 95% CI)	1.39 [0.81, 2.38]
3.4 Fluoxetine vs Bupropion	2	436	Odds Ratio (M‐H, Random, 95% CI)	1.00 [0.67, 1.48]
3.5 Fluoxetine vs Nefazodone	3	161	Odds Ratio (M‐H, Random, 95% CI)	0.54 [0.22, 1.31]
3.6 Fluoxetine vs Pramipexole	1	105	Odds Ratio (M‐H, Random, 95% CI)	0.12 [0.03, 0.42]
3.7 Fluoxetine vs Tianeptine	3	830	Odds Ratio (M‐H, Random, 95% CI)	0.96 [0.69, 1.33]
3.8 Fluoxetine vs Trazodone	4	230	Odds Ratio (M‐H, Random, 95% CI)	0.51 [0.23, 1.13]
4 Failure to complete ‐ Inefficacy	14		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Fluoxetine vs ABT‐200	1	144	Odds Ratio (M‐H, Random, 95% CI)	0.24 [0.03, 2.20]
4.2 Fluoxetine vs Amineptine	1	63	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.19, 5.57]
4.3 Fluoxetine vs Amisulpride	1	281	Odds Ratio (M‐H, Random, 95% CI)	1.16 [0.43, 3.10]
4.4 Fluoxetine vs Bupropion	2	436	Odds Ratio (M‐H, Random, 95% CI)	1.16 [0.33, 4.10]
4.5 Fluoxetine vs Nefazodone	3	161	Odds Ratio (M‐H, Random, 95% CI)	0.71 [0.05, 10.71]
4.6 Fluoxetine vs Pramipexole	1	105	Odds Ratio (M‐H, Random, 95% CI)	0.49 [0.05, 4.51]
4.7 Fluoxetine vs Tianeptine	3	830	Odds Ratio (M‐H, Random, 95% CI)	0.82 [0.27, 2.53]
4.8 Fluoxetine vs Trazodone	2	70	Odds Ratio (M‐H, Random, 95% CI)	0.23 [0.04, 1.51]
5 Failure to complete ‐ Side Effects	17		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Fluoxetine vs ABT‐200	1	144	Odds Ratio (M‐H, Random, 95% CI)	0.08 [0.02, 0.27]
5.2 Fluoxetine vs Amineptine	2	232	Odds Ratio (M‐H, Random, 95% CI)	0.52 [0.03, 7.82]
5.3 Fluoxetine vs Amisulpride	1	281	Odds Ratio (M‐H, Random, 95% CI)	0.77 [0.33, 1.82]
5.4 Fluoxetine vs Bupropion	2	436	Odds Ratio (M‐H, Random, 95% CI)	1.01 [0.45, 2.25]
5.5 Fluoxetine vs Nefazodone	4	286	Odds Ratio (M‐H, Random, 95% CI)	0.76 [0.32, 1.81]
5.6 Fluoxetine vs Pramipexole	1	105	Odds Ratio (M‐H, Random, 95% CI)	0.06 [0.01, 0.50]
5.7 Fluoxetine vs Tianeptine	3	830	Odds Ratio (M‐H, Random, 95% CI)	1.13 [0.71, 1.80]
5.8 Fluoxetine vs Trazodone	3	110	Odds Ratio (M‐H, Random, 95% CI)	0.66 [0.20, 2.19]