Comparison 9. Subgroup analysis for fluoxetine versus TCAs: endpoint score.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 follow‐up <6 weeks	12	541	Std. Mean Difference (IV, Random, 95% CI)	0.18 [‐0.15, 0.50]
1.1 Fluoxetine vs Amiptriptyline	6	290	Std. Mean Difference (IV, Random, 95% CI)	0.39 [‐0.25, 1.02]
1.2 Fluoxetine vs Clomipramine	2	124	Std. Mean Difference (IV, Random, 95% CI)	‐0.00 [‐0.36, 0.35]
1.3 Fluoxetine vs Desipramine	1	26	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.72, 0.82]
1.4 Fluoxetine vs Imipramine	2	60	Std. Mean Difference (IV, Random, 95% CI)	‐0.04 [‐1.31, 1.22]
1.5 Fluoxetine vs Trimipramine	1	41	Std. Mean Difference (IV, Random, 95% CI)	0.38 [‐0.24, 1.00]
2 follow‐up 6‐16 weeks	36	2727	Std. Mean Difference (IV, Random, 95% CI)	0.04 [‐0.06, 0.14]
2.1 Fluoxetine vs Amiptriptyline	13	733	Std. Mean Difference (IV, Random, 95% CI)	0.07 [‐0.07, 0.22]
2.2 Fluoxetine vs Clomipramine	3	248	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.40, 0.10]
2.3 Fluoxetine vs Desipramine	3	121	Std. Mean Difference (IV, Random, 95% CI)	0.33 [‐0.47, 1.12]
2.4 Fluoxetine vs Dothiepin/dosulepin	4	266	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.27, 0.59]
2.5 Fluoxetine vs Imipramine	10	1003	Std. Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.21, 0.19]
2.6 Fluoxetine vs Lofepramine	1	183	Std. Mean Difference (IV, Random, 95% CI)	0.13 [‐0.16, 0.42]
2.7 Fluoxetine vs Nortriptyline	1	154	Std. Mean Difference (IV, Random, 95% CI)	‐0.12 [‐0.44, 0.20]
2.8 Fluoxetine vs Trimipramine	1	19	Std. Mean Difference (IV, Random, 95% CI)	0.47 [‐0.44, 1.39]
3 follow‐up >16 weeks	1	97	Std. Mean Difference (IV, Random, 95% CI)	‐0.86 [‐1.27, ‐0.44]
3.1 Fluoxetine vs Nortriptyline	1	97	Std. Mean Difference (IV, Random, 95% CI)	‐0.86 [‐1.27, ‐0.44]