Altamura 1989.

Methods	Five‐week double‐blind randomised study
Participants	Inpatients fulfilling DSM‐III criteria for major depressive episode and scoring at least 18 on Hamilton Rating Scale for Depression‐17 item (HDRS‐17). Age: over 65 years Exclusion criteria: not reported
Interventions	Fluoxetine: 13 participants Amitriptyline: 15 participants Fluoxetine dose: 20 mg/day Amitriptyline dose: 75 mg/day
Outcomes	HDRS‐17 score
Notes	Elderly patients only Funding: unclear
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "randomised". No other information
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Quote: "double blind". No further information
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "double blind". No further information
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Quote: "double blind". No further information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Number of dropouts reported, but reasons not specified Scores reported without denominator
Selective reporting (reporting bias)	Unclear risk	Endpoint scores reported only in figure. Only most common side effects reported
Other bias	Unclear risk	Funding: unclear