Andreoli 2002.

Methods	Eight‐week double‐blind, randomised multicentre study
Participants	In and outpatients meeting DSM‐III‐R diagnostic criteria for major depression, with a minimum baseline score of 22 on the Hamilton Rating Scale for Depression‐21 item (HDRS‐21), recruited from 33 clinical sites. Age range: 18‐65 years Exclusion criteria: history of unresponsiveness to antidepressant treatment, association with endocrine disorders, substance abuse, drug hypersensitivity, chronic respiratory insufficiency, or gastro‐intestinal, hepatic or renal disease, ECT within 6 months of baseline, high risk of suicide, pregnancy or absence of adequate contraception measures.
Interventions	Fluoxetine: 127 participants Reboxetine: 126 participants Placebo: 128 participants Fluoxetine dose range: 20‐40 mg/day Reboxetine dose range: 8‐10 mg/day Chloral hydrate (0.5‐1 g) was allowed as hypnotic
Outcomes	Primary outcome: absolute change in the HDRS‐21 total score Secondary outcomes: Clinical Global Impression Scale (CGI) Severity and Improvement, Montgomery and Asberg Scale for Depression (MADRS), Quality of Sleep Questionnaire
Notes	Response: decrease of at least 50% in the HDRS total score Remission: total score less than 10 Funding: unclear
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised trial, no further information
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding (performance bias and detection bias) All outcomes	Unclear risk	"Double blind", no further information
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	"Double blind", no further information
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	"Double blind", no further information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Number of randomised and number of lost during follow‐up reported, but the reasons for dropout were not clear. Only most common side effects were reported Quote: "Statistical analysis was carried out on the intent to treat population"
Selective reporting (reporting bias)	Unclear risk	Only most common side effects were reported Mean endpoint scores and standard deviation reported
Other bias	Unclear risk	Funding: unclear