Hosak 2000.

Methods	Four‐week, randomised and open study
Participants	Hospitalized patients. Diagnoses for inclusion (according to the ICD‐10) were: bipolar affective disorder, most recent episode depressed (8 participants); major depressive episode, single (44 participants), major depressive episode, recurrent (38 participants). Average age: 44.5 years (SD: 14.3)
Interventions	Citalopram: 29 participants Amitriptyline: 31 participants Fluoxetine: 30 participants Citalopram dose range: 20‐60 mg/day Amitriptyline dose range: 150‐300 mg/day Fluoxetine: 20‐60 mg/day
Outcomes	Mean change on Hamilton Depression Rating Scale‐21 item (HDRS‐21)
Notes	Study report published only in Czech Funding: unclear
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "the subjects were randomised to the study antidepressant using computer randomisation program (Excel) at the beginning of the initial hospitalisation at the Dpt. of Psychiatry in Hradec Kralovc"
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information provided
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided
Incomplete outcome data (attrition bias) All outcomes	High risk	No information provided
Selective reporting (reporting bias)	High risk	No information provided
Other bias	Unclear risk	Funding: unclear