Kwon 1996.

Methods	Six‐week randomised, double‐blind study
Participants	Outpatients fulfilling DSM‐III‐R criteria for unipolar major depression, drug free for a minimum of 2 weeks. Mean age: 44,31 years (SD=9,31) Exclusion criteria: previously received ECT; neurological disorders and major illness.
Interventions	Twenty participants were randomly assigned to a 6‐weeks of treatment with fluoxetine or amitriptyline No other information about the interventions
Outcomes	Hamilton Rating Scale for Depression (HDRS) was assessed at baseline and at the end of the 6th week Response: a reduction of at least 50% of the HDRS score
Notes	Funding: by academy
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "randomly assigned", no other information
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Quote: "randomly assigned by an another psychiatrist who was blind to the rating of HDRS", no further information
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "Randomly assigned by an another psychiatrist who was blind to the rating of HDRS", no further information
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided
Incomplete outcome data (attrition bias) All outcomes	High risk	Only the total number of randomised patients was reported, the number of participants in each group was not reported. Number and reason for dropout not reported
Selective reporting (reporting bias)	High risk	Side effects not reported. Baseline and endpoint score reported for the whole group
Other bias	Low risk	Quote: "this work was supported by grant N°. 02‐94‐158 from the Seoul National University Hospital research found"