Mowla 2006.

Methods	Eight‐week randomised, double‐blind study
Participants	Outpatients fulfilling DSM‐IV criteria for major depression disorder, based on a structured clinical interview. Mean age: 30.8 (SD: 9.9) (fluoxetine) and 35 (SD: 9.4) (nortriptyline) years Exclusion criteria: patients with another DSM‐IV diagnosis, psychotic symptoms, alcohol or other drugs addiction, major physical illness, potentially pregnant women, breast‐feeding or planning to be pregnant in the next two months, patients in whom tricyclics were contraindicated (i.e. narrow‐angle glaucoma, prostatism).
Interventions	Fluoxetine: 36 participants Nortriptyline : 20 participants Fluoxetine dose: 40 mg/day Nortriptyline dose: 150 mg/day
Outcomes	Primary outcomes: change in Hamilton Rating Scale for Depression (HDRS) and in Clinical Global Impression (CGI) total scores
Notes	Funding: unclear
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised, no further information
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Double blind, no further information
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "the investigator was blind as to medications and he did not personally manage any patients in the study", no further information
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Double blind, no further information
Incomplete outcome data (attrition bias) All outcomes	High risk	Number of dropouts was reported, but the reasons were not clearly described. Endpoint scores not reported (HDRS, CGI)
Selective reporting (reporting bias)	High risk	Side effects not reported. Item in which there was significant improvement reported without mean and standard deviation
Other bias	Unclear risk	Funding: unclear